Trigger Strategy in Clinical Trials

Documentation for package ‘triggerstrategy’ version 1.2.0

alpha2boundary	Convert cumulative alpha levels to normal critical boundaries
boundary2alpha	Convert normal critical boundaries to cumulative alpha levels.
corrMatGenerator	Correlation matrix generator
gbounds	Critical boundary in group sequential trials
marginalPwR	Marginal Power Rate
psPwRbhmb	Powers of testing the primary and secondary hypotheses
psPwRtrigger	Powers of testing the primary and secondary hypotheses using trigger strategy
sBoundsPh2	Critical boundaries for the secondary endpoint in the partially hierarchical group sequential design
sErrRphInt2	Type I error rate of the overall null hypothesis using the partial hierarchical design
solveAlphaXsampleSize	Sample size calculation
solveAlphaXsampleSizeGA	Sample size calculation using Genetic Algorithms
sPwRholm	Power of testing the secondary hypothesis using Holm
sPwRholmye	Power of testing the secondary hypothesis using Holm-Ye
sPwRnaiveBonf	Power of testing the secondary hypothesis using Bonferroni
sPwRph2	Power of testing the secondary hypothesis in partially hierarchical design
sPwRtrigger	Power of testing the secondary hypothesis using Trigger strategy